Animal Quantitative Genetics

We are developing methods that underpin forward and reverse genetic approaches for the identification of causative genes and variants, the study of meiotic recombination and gene conversion, and to infer the demographic history of populations.

We are the academic group driving the implementation of genomic selection in the Belgian Blue Cattle Breed in close collaboration with the Walloon Breeding Organisation.         

Key publications

A model-based approach to characterize individual inbreeding at both global and local genomic scales. Druet T, Gautier M. Mol Ecol 26: 5820-5841 (2017)

Coding and non-coding variants in HFM1, MLH3, MSH4, MSH5, RNF212 and RNF21Z2B affect recombination rate in cattle. Kadri NK, Harland C, Faux P, Cambisano N, Karim L, Coppieters W, Fritz S, Mullaart E, Baurain D, Boichard D, Spelman R, Charlier C, Georges M, Druet TGenome Res 26: 1323-1332 (2016)

Towards genomic prediction from whole genome sequence data: impact of sequencing design on genotype imputation and accuracy of prediction. Druet T, Macleod IM, Hayes BJ. Heredity 112:39-47 (2014)

A 660-Kb deletion with antagonistic effects on fertility and milk production segregates at high frequency in Nordic Red cattle: additional evidence for the common occurrence of balancing selection in livestock. Kumar Kadri N, Sahana G, Charlier C, Iso-Touru T, Guldbrandten B, Karim L, Nielsen US, Panitz F, Aamand GP, Schulman N, Georges M, Vilkki J, Lund MS, Druet TPloS Genetics 10:E1004049 (2014)

Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature. Karim L*, Takeda H*, Lin L*, Druet T*, Arias JAC, Baurain D, Cambisano N, Davis SR, Farnir F, Grisart B, Harris BL, Keehan MD, Littlejohn MD, Spelman RJ, Georges M, Coppieters W. *co-first. Nat Genetics 43: 405-413 (2011)

A hidden markov model combining linkage and linkage disequilibrium information for haplotype reconstruction and quantitative trait locus fine mapping. Druet T, Georges M. Genetics 184:789-798 (2010)

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