IBD Genomics

We are zooming in the 200 plus GWAS peaks that have been identified over the last ten years for Crohn’s disease and/or ulcerative colitis. Our aim is to identify the corresponding causative variants and genes as a way to pinpoint putative drug targets and develop better diagnostic tools.  To that end, we continue to generate various “omic” data in disease relevant cell-types for hundreds of healthy and diseased individuals including for eQTL and microbiome analyses.

Key publications

IBD risk loci are enriched in multigenic regulatory modules encompassing causative genes. Momozawa Y, Dmitrieva J, Theatre E, Deffontaine V, Rahmouni S, Charloteaux B, Crins F, Docampo E, Elansary M, Gori A-S, Lecut C, Mariman R, Mni M, Oury C, Altukhov I, Alexeev D, Aulchenko Y, Amininiejad L, Boum G, Hoentjen F, Lowenberg M, Oldenburg B, Pierik MJ, van der Meulen-de Jong AE, van der Woude CJ, Visschedijk MC, The IIBDGC, Lathrop M, Hugot J-P, Weersma RK, De Vos M, Franchimont D, Vermeire S, Kubo M, Louis E, Georges MNat Commun 9:2427 (2018)

Association mapping of inflammatory bowel disease loci to single variant resolution. Huang H*, Fang M*, Jostins L*, Umicevic Mirkov M, Boucher G, Anderson CA, Andersen V, Cleynen I, Cortes A, Crins F, D'Amato M, Deffontaine V, Dmitrieva J, Docampo E, Elansary M, Kai-How Farh K, Franke A, Gori A-S, Goyette P, Halfvarson, Haritunians T, Knight J, Lawrance IC, Lees CW, Louis E, Mariman R, Meuwissen T, Mni M, Momozawa Y, Parkes M, Spain SL, Theatre E, Trynka G, Satsangi J, van Sommeren S, Vermeire S, Xavier RJ, IIBDGC, Weersma R, Duerr RH, Mathew CG, Rioux JD, McGovern DPB, Cho JH, Georges M#, Daly M#, Barrett JC.# *co-first, #co-senior Nature 547: 173-178 (2017)

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Momozawa Y, Mni M, Nakamura K, Coppieters W, Almer S, Amininejad L, Dewit O, Finkel Y,Gassuli MA, Goossens D, Laukens D, Lémann M, Libioulle C, O'Morain C, Reenaers C, Rutgeerts P, Tysk C, Zelenika D, Lathrop M, Del-Favero J, Hugot JP, de Vos M, Franchimont D, Vermeire S, Louis E, Georges MNat Genetics 43:43-47 (2011)

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ; NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ. Nat Genetics 40:955-962 (2008)

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. Libioulle C, Louis E, Hansoul S, Sandor C, Farnir F, Franchimont D, Vermeire S, Dewit O, de Vos M, Dixon A, Demarche B, Gut I, Heath S, Foglio M, Liang L, Laukens D, Mni M, Zelenika D, Van Gossum A, Rutgeerts P, Belaiche J, Lathrop M, Georges MPLoS Genetics 3:e58 (2007)

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