Publications


2022

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility. Sazonovs A, Stevens CR, Venkataraman GR, Yuan K, Avila B, Abreu MT, Ahmad T, Allez M, Ananthakrishnan AN, Atzmon G, Baras A, Barrett JC, Barzilai N, Beaugerie L, Beecham A, Bernstein CN, Bitton A, Bokemeyer B, Chan A, Chung D, Cleynen I, Cosnes J, Cutler DJ, Daly A, Damas OM, Datta LW, Dawany N, Devoto M, Dodge S, Ellinghaus E, Fachal L, Farkkila M, Faubion W, Ferreira M, Franchimont D, Gabriel SB, Ge T, Georges M, Gettler K, Giri M, Glaser B, Goerg S, Goyette P, Graham D, Hämäläinen E, Haritunians T, Heap GA, Hiltunen M, Hoeppner M, Horowitz JE, Irving P, Iyer V, Jalas C, Kelsen J, Khalili H, Kirschner BS, Kontula K, Koskela JT, Kugathasan S, Kupcinskas J, Lamb CA, Laudes M, Lévesque C, Levine AP, Lewis JD, Liefferinckx C, Loescher BS, Louis E, Mansfield J, May S, McCauley JL, Mengesha E, Mni M, Moayyedi P, Moran CJ, Newberry RD, O'Charoen S, Okou DT, Oldenburg B, Ostrer H, Palotie A, Paquette J, Pekow J, Peter I, Pierik MJ, Ponsioen CY, Pontikos N, Prescott N, Pulver AE, Rahmouni S, Rice DL, Saavalainen P, Sands B, Sartor RB, Schiff ER, Schreiber S, Schumm LP, Segal AW, Seksik P, Shawky R, Sheikh SZ, Silverberg MS, Simmons A, Skeiceviciene J, Sokol H, Solomonson M, Somineni H, Sun D, Targan S, Turner D, Uhlig HH, van der Meulen AE, Vermeire S, Verstockt S, Voskuil MD, Winter HS, Young J; Belgium IBD Consortium; Cedars-Sinai IBD; International IBD Genetics Consortium; NIDDK IBD Genetics Consortium; NIHR IBD BioResource; Regeneron Genetics Center; SHARE Consortium; SPARC IBD Network; UK IBD Genetics Consortium, Duerr RH, Franke A, Brant SR, Cho J, Weersma RK, Parkes M, Xavier RJ, Rivas MA, Rioux JD, McGovern DPB, Huang H, Anderson CA, Daly MJ. Nat Genet. 2022 Aug 29. doi: 10.1038/s41588-022-01156-2.
 
PI3Kδ activity controls plasticity and discriminates between EMT and stemness based on distinct TGFβ signaling. Agnetti J, Bou Malham V, Desterke C, Benzoubir N, Peng J, Jacques S, Rahmouni S, Di Valentin E, Tan TZ, Samuel D, Thiery JP, Gassama-Diagne A.Commun Biol 5:740 (2022).
 

A hidden Markov model to estimate homozygous-by-descent probabilities associated with nested layers of ancestors. Druet T, Gautier M. Theor Popul Biol 145:38-51 (2022).

Association Between Human Gut Microbiome and N-Glycan Composition of Total Plasma Proteome. Petrov VA, Sharapov SZ, Shagam L, Nostaeva AV, Pezer M, Li D, Hanić M, McGovern D, Louis E, Rahmouni S, Lauc G, Georges M, Aulchenko YS. Front Microbiol 13:811922 (2022).
 
ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs. Yang H, Wu J, Huang X, Zhou Y, Zhang Y, Liu M, Liu Q, Ke S, He M, Fu H, Fang S, Xiong X, Jiang H, Chen Z, Wu Z, Gong H, Tong X, Huang Y, Ma J, Gao J, Charlier C, Coppieters W, Shagam L, Zhang Z, Ai H, Yang B, Georges M*, Chen C*, Huang L*. Nature 606:358-367 (2022). Co-senior and co-cerrespponding authors.
 

Evaluation of Screening Program and Phylogenetic Analysis of SARS-CoV-2 Infections among Hospital Healthcare Workers in Liège, Belgium. El Moussaoui M, Maes N, Hong SL, Lambert N, Gofflot S, Dellot P, Belhadj Y, Huynen P, Hayette MP, Meex C, Bontems S, Defêche J, Godderis L, Molenberghs G, Meuris C, Artesi M, Durkin K, Rahmouni S, Grégoire C, Beguin Y, Moutschen M, Dellicour S, Darcis G. Viruses 14:1302 (2022).

Kinetics and Persistence of the Cellular and Humoral Immune Responses to BNT162b2 mRNA Vaccine in SARS-CoV-2-Naive and -Experienced Subjects: Impact of Booster Dose and Breakthrough Infections. Desmecht S, Tashkeev A, El Moussaoui M, Marechal N, Perée H, Tokunaga Y, Fombellida-Lopez C, Polese B, Legrand C, Wéry M, Mni M, Fouillien N, Toussaint F, Gillet L, Bureau F, Lutteri L, Hayette MP, Moutschen M, Meuris C, Vermeersch P, Desmecht D, Rahmouni S, Darcis G. Front Immunol 13:863554 (2022).

Novel genes and sex differences in COVID-19 severity. Cruz R, Almeida SD, Heredia ML, Quintela I, Ceballos FC, Pita G, Lorenzo-Salazar JM, González-Montelongo R, Gago-Domínguez M, Porras MS, Castaño JAT, Nevado J, Aguado JM, Aguilar C, Aguilera-Albesa S, Almadana V, Almoguera B, Alvarez N, Andreu-Bernabeu Á, Arana-Arri E, Arango C, Arranz MJ, Artiga MJ, Baptista-Rosas RC, Barreda-Sánchez M, Belhassen-Garcia M, Bezerra JF, Bezerra MAC, Boix-Palop L, Brion M, Brugada R, Bustos M, Calderón EJ, Carbonell C, Castano L, Castelao JE, Conde-Vicente R, Cordero-Lorenzana ML, Cortes-Sanchez JL, Corton M, Darnaude MT, De Martino-Rodríguez A, Campo-Pérez V, Bustamante AD, Domínguez-Garrido E, Luchessi AD, Eirós R, Sanabria GME, Fariñas MC, Fernández-Robelo U, Fernández-Rodríguez A, Fernández-Villa T, Gil-Fournier B, Gómez-Arrue J, Álvarez BG, Quirós FGB, González-Peñas J, Gutiérrez-Bautista JF, Herrero MJ, Herrero-Gonzalez A, Jimenez-Sousa MA, Lattig MC, Borja AL, Lopez-Rodriguez R, Mancebo E, Martín-López C, Martín V, Martinez-Nieto O, Martinez-Lopez I, Martinez-Resendez MF, Martinez-Perez Á, Mazzeu JA, Macías EM, Minguez P, Cuerda VM, Silbiger VN, Oliveira SF, Ortega-Paino E, Parellada M, Paz-Artal E, Santos NPC, Pérez-Matute P, Perez P, Pérez-Tomás ME, Perucho T, Pinsach-Abuin ML, Pompa-Mera EN, Porras-Hurtado GL, Pujol A, León SR, Resino S, Fernandes MR, Rodríguez-Ruiz E, Rodriguez-Artalejo F, Rodriguez-Garcia JA, Ruiz-Cabello F, Ruiz-Hornillos J, Ryan P, Soria JM, Souto JC, Tamayo E, Tamayo-Velasco A, Taracido-Fernandez JC, Teper A, Torres-Tobar L, Urioste M, Valencia-Ramos J, Yáñez Z, Zarate R, Nakanishi T, Pigazzini S, Degenhardt F, Butler-Laporte G, Maya-Miles D, Bujanda L, Bouysran Y, Palom A, Ellinghaus D, Martínez-Bueno M, Rolker S, Amitrano S, Roade L, Fava F, Spinner CD, Prati D, Bernardo D, Garcia F, Darcis G, Fernández-Cadenas I, Holter JC, Banales JM, Frithiof R, Duga S, Asselta R, Pereira AC, Romero-Gómez M, Nafría-Jiménez B, Hov JR, Migeotte I, Renieri A, Planas AM, Ludwig KU, Buti M, Rahmouni S, Alarcón-Riquelme ME, Schulte EC, Franke A, Karlsen TH, Valenti L, Zeberg H, Richards B, Ganna A, Boada M, Rojas I, Ruiz A, Sánchez P, Real LM; SCOURGE Cohort Group; HOSTAGE Cohort Group; GRA@CE Cohort Group, Guillen-Navarro E, Ayuso C, González-Neira A, Riancho JA, Rojas-Martinez A, Flores C, Lapunzina P, Carracedo Á. Hum Mol Genet ddac132 (2022).

Endothelial extracellular vesicles promote tumour growth by tumour-associated macrophage reprogramming. Njock MS, O'Grady T, Nivelles O, Lion M, Jacques S, Cambier M, Herkenne S, Muller F, Christian A, Remacle C, Guiot J, Rahmouni S, Dequiedt F, Struman I. J Extracell Vesicles 11:e12228 (2022).

Benchmarking phasing software with a whole-genome sequenced cattle pedigree. Oget-Ebrad C, Kadri NK, Moreira GCM, Karim L, Coppieters W, Georges M, Druet T. BMC Genomics 23:130 (2022).
 
Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs. Zhu Y, Zhou Z, Huang T, Zhang Z, Li W, Ling Z, Jiang T, Yang J, Yang S, Xiao Y, Charlier C, Georges M, Yang B, Huang L. Sci China Life Sci 65:1517-1534 (2022).
 

The genetic history of Mayotte and Madagascar cattle breeds mirrors the complex pattern of human exchanges in Western Indian Ocean. Magnier J, Druet T, Naves M, Ouvrard M, Raoul S, Janelle J, Moazami-Goudarzi K, Lesnoff M, Tillard E, Gautier M, Flori L. G3 (Bethesda) 12:jkac029 (2022).

Analysis of Autozygosity Using Whole-Genome Sequence Data of Full-Sib Families in Pikeperch ( Sander lucioperca). De Los Ríos-Pérez L, Druet T, Goldammer T, Wittenburg D. Front Genet 12:786934 (2022).

2021 

Mapping the human genetic architecture of COVID-19. COVID-19 Host Genetics Initiative. Nature 600:472-477 (2021).

In-Depth Longitudinal Comparison of Clinical Specimens to Detect SARS-CoV-2. Defêche J, Azarzar S, Mesdagh A, Dellot P, Tytgat A, Bureau F, Gillet L, Belhadj Y, Bontems S, Hayette MP, Schils R, Rahmouni S, Ernst M, Moutschen M, Darcis G. Pathogens 10:1362 (2021).

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. Nakanishi T, Pigazzini S, Degenhardt F, Cordioli M, Butler-Laporte G, Maya-Miles D, Bujanda L, Bouysran Y, Niemi ME, Palom A, Ellinghaus D, Khan A, Martínez-Bueno M, Rolker S, Amitrano S, Roade Tato L, Fava F; FinnGen; COVID-19 Host Genetics Initiative (HGI), Spinner CD, Prati D, Bernardo D, Garcia F, Darcis G, Fernández-Cadenas I, Holter JC, Banales JM, Frithiof R, Kiryluk K, Duga S, Asselta R, Pereira AC, Romero-Gómez M, Nafría-Jiménez B, Hov JR, Migeotte I, Renieri A, Planas AM, Ludwig KU, Buti M, Rahmouni S, Alarcón-Riquelme ME, Schulte EC, Franke A, Karlsen TH, Valenti L, Zeberg H, Richards JB, Ganna A. J Clin Invest 131:e152386 (2021).

Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR. Scherer M, Gasparoni G, Rahmouni S, Shashkova T, Arnoux M, Louis E, Nostaeva A, Avalos D, Dermitzakis ET, Aulchenko YS, Lengauer T, Lyons PA, Georges M, Walter J. Epigenetics Chromatin 14:44 (2021).

The genetic deletion of the Dual Specificity Phosphatase 3 (DUSP3) attenuates kidney damage and inflammation following ischaemia/reperfusion injury in mouse. Khbouz B, Rowart P, Poma L, Dahlke E, Bottner M, Stokes M, Bolen G, Rahmouni S, Theilig F, Jouret F. Acta Physiol (Oxf) 27:e13735 (2021).

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. Nakanishi T, Pigazzini S, Degenhardt F, Cordioli M, Butler-Laporte G, Maya-Miles D, Bujanda L, Bouysran Y, Niemi ME, Palom A, Ellinghaus D, Khan A, Martínez-Bueno M, Rolker S, Amitrano S, Roade Tato L, Fava F, Spinner CD, Prati D, Bernardo D, Garcia F, Darcis G, Fernandez-Cadenas I, Holter JC, Banales JM, Frithiof R, Kiryluk K, Duga S, Asselta R, Pereira AC, Romero-Gómez M, Nafría-Jiménez B, Hov JR, Migeotte I, Renieri A, Planas AM, Ludwig KU, Buti M, Rahmouni S, Alarcón-Riquelme ME, Schulte EC, Franke A, Karlsen TH, Valenti L, Zeberg H, Richards JB, Ganna A. J Clin Invest 1:e152386 (2021).

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Võsa U, Claringbould A, Westra HJ, Bonder MJ, Deelen P, Zeng B, Kirsten H, Saha A, Kreuzhuber R, Yazar S, Brugge H, Oelen R, de Vries DH, van der Wijst MGP, Kasela S, Pervjakova N, Alves I, Favé MJ, Agbessi M, Christiansen MW, Jansen R, Seppälä I, Tong L, Teumer A, Schramm K, Hemani G, Verlouw J, Yaghootkar H, Sönmez Flitman R, Brown A, Kukushkina V, Kalnapenkis A, Rüeger S, Porcu E, Kronberg J, Kettunen J, Lee B, Zhang F, Qi T, Hernandez JA, Arindrarto W, Beutner F; BIOS Consortium; i2QTL Consortium, Dmitrieva J, Elansary M, Fairfax BP, Georges M, Heijmans BT, Hewitt AW, Kähönen M, Kim Y, Knight JC, Kovacs P, Krohn K, Li S, Loeffler M, Marigorta UM, Mei H, Momozawa Y, Müller-Nurasyid M, Nauck M, Nivard MG, Penninx BWJH, Pritchard JK, Raitakari OT, Rotzschke O, Slagboom EP, Stehouwer CDA, Stumvoll M, Sullivan P, 't Hoen PAC, Thiery J, Tönjes A, van Dongen J, van Iterson M, Veldink JH, Völker U, Warmerdam R, Wijmenga C, Swertz M, Andiappan A, Montgomery GW, Ripatti S, Perola M, Kutalik Z, Dermitzakis E, Bergmann S, Frayling T, van Meurs J, Prokisch H, Ahsan H, Pierce BL, Lehtimäki T, Boomsma DI, Psaty BM, Gharib SA, Awadalla P, Milani L, Ouwehand WH, Downes K, Stegle O, Battle A, Visscher PM, Yang J, Scholz M, Powell J, Gibson G, Esko T, Franke L. Nat Genet 53:1300-1310 (2021).

A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle. Lee YL, Takeda H, Costa Monteiro Moreira G, Karim L, Mullaart E, Coppieters W; GplusE consortium, Appeltant R, Veerkamp RF, Groenen MAM, Georges M, Bosse M, Druet T, Bouwman AC, Charlier C. PLoS Genet 17:e1009331 (2021).

Non-additive association analysis using proxy phenotypes identifies novel cattle syndromes. Reynolds EGM, Neeley C, Lopdell TJ, Keehan M, Dittmer K, Harland CS, Couldrey C, Johnson TJJ, Tiplady K, Worth G, Walker M, Davis SR, Sherlock RG, Carnie K, Harris BL, Charlier C, Georges M, Spelman RJ, Garrick DJ, Littlejohn MD. Nat Genet 53:949-954 (2021).

New approach to determine the healthy immune variations by combining clustering methods. Liefferinckx C, De Grève Z, Toubeau JF, Perée H, Quertinmont E, Tafciu V, Minsart C, Rahmouni S, Georges M, Vallée F, Franchimont D. Sci Rep 11:8917 (2021).

Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate. Rapino F, Zhou Z, Roncero Sanchez AM, Joiret M, Seca C, El Hachem N, Valenti G, Latini S, Shostak K, Geris L, Li P, Huang G, Mazzucchelli G, Baiwir D, Desmet CJ, Chariot A, Georges M, Close P. Nat Commun 12:2170 (2021).

PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads. Artesi M, Hahaut V, Cole B, Lambrechts L, Ashrafi F, Marçais A, Hermine O, Griebel P, Arsic N, van der Meer F, Burny A, Bron D, Bianchi E, Delvenne P, Bours V, Charlier C, Georges M, Vandekerckhove L, Van den Broeke A, Durkin K. Genome Biol 22:97 (2021).

Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype. Marçais A, Lhermitte L, Artesi M, Laurent C, Durkin K, Hahaut V, Rosewick N, Suarez F, Sibon D, Cheminant M, Avettand-Fenoel V, Bruneau J, Georges M, Pique C, Van den Broeke A, Asnafi V, Hermine O. Leukemia 35:764-776 (2021).

An evaluation of inbreeding measures using a whole-genompe sequenced cattle pedigree. Alemu SW, Kadri NK, Harland C, Faux P, Charlier C, Caballero A, Druet T. Heredity 126: 410-423 (2021).

Dual-specificity phosphatase 3 deletion promotes obesity, non-alcoholic steatohepatitis and hepatocellular carcinoma.Jacques S, Arjomand A, Perée H, Collins P, Mayer A, Lavergne A, Wéry M, Mni M, Thuillier V, Becker G, Ali Bahri M, Plenevaux A, Di Valentin E, Oury C, Moutschen M, Delvenne P, Paquot N, Rahmouni S. Sci Rep 11:5817 (2021).

Alzheimer's disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness. Muto V, Koshmanova E, Ghaemmaghami P, Jaspar M, Meyer C, Elansary M, Van Egroo M, Chylinski D, Berthomier C, Brandewinder M, Mouraux C, Schmidt C, Hammad G, Coppieters W, Ahariz N, Degueldre C, Luxen A, Salmon E, Phillips C, Archer SN, Yengo L, Byrne E, Collette F, Georges M, Dijk DJ, Maquet P, Visscher PM, Vandewalle G. Sleep 44:zsaa137 (2021).

2020

On the estimation of inbreeding depression using different measures of inbreeding from molecular markers.Caballero A, Villanueva B, Druet T.  Evol Appl.14:416-428 (2020)

An improved sequencing-based bioinformatics pipeline to track the distribution and clonal architecture of proviral integration sites. Rosewick N, Hahaut V, Durkin K, Artesi M, Karpe S, Wayet J, Griebel PJ, Arsic N, Marçais A, Burny A, Hermine O, Georges M, Van Den Broeke A. Front Microbiol 11: 587306 (2020).

CRELD1 modulates homeostasis of the immune system in mouse and humans. Bonaguro L, Köhne M, Schmidleithner L, Warnat-Herresthal S, Schute-Schrepping J, Kern P, Günther P, Horne A, ter Horst R, Jaeger M, Rahmouni S, Georges M, Falk C, Li Y, Mass E, Beyer M, Jossten LAB, Netea MG, Ulas T, Schultze JL, Aschenbrenner AC. Nature Immunology 21: 1517-1527 (2020).

The polygenic and monogenic basis of blood cell traits and diseases. Vuckovic D, Bao EL, Akbari P, Lareau CA, Mousas A, Jiang T, Chen MH, Raffield LM, Tardaguila M, Huffman JE, Ritchie SC, Megy K, Ponstingl H, Penkett CJ, Albers PK, Wigdor EM, Sakaue S, Moscati A, Manansala R, Lo KS, Qian H, Akiyama M, Bartz TM, Ben-Shlomo Y, Beswick A, Bork-Jensen J, Bottinger EP, Brody JA, van Rooij FJA, Chitrala KN, Wilson PWF, Choquet H, Danesh J, Di Angelantonio E, Dimou N, Ding J, Elliott P, Esko T, Evans MK, Felix SB, Floyd JS, Broer L, Grarup N, Guo MH, Guo Q, Greinacher A, Haessler J, Hansen T, Howson JMM, Huang W, Jorgenson E, Kacprowski T, Kähönen M, Kamatani Y, Kanai M, Karthikeyan S, Koskeridis F, Lange LA, Lehtimäki T, Linneberg A, Liu Y, Lyytikäinen LP, Manichaikul A, Matsuda K, Mohlke KL, Mononen N, Murakami Y, Nadkarni GN, Nikus K, Pankratz N, Pedersen O, Preuss M, Psaty BM, Raitakari OT, Rich SS, Rodriguez BAT, Rosen JD, Rotter JI, Schubert P, Spracklen CN, Surendran P, Tang H, Tardif JC, Ghanbari M, Völker U, Völzke H, Watkins NA, Weiss S; VA Million Veteran Program, Cai N, Kundu K, Watt SB, Walter K, Zonderman AB, Cho K, Li Y, Loos RJF, Knight JC, Georges M, Stegle O, Evangelou E, Okada Y, Roberts DJ, Inouye M, Johnson AD, Auer PL, Astle WJ, Reiner AP, Butterworth AS, Ouwehand WH, Lettre G, Sankaran VG, Soranzo N. Cell 182: 1214-1231.e11 (2020).

Color-sidedness in Gloucester cattle is associated with a complex structural variant impacting regulatory elements downstream of KIT. Artesi M, Tamma N, Deckers M, Karim L, Coppieters W, Van den Broeke A, georges M, Charlier C, Durkin K. Animal Genetics 51: 461-465 (2020).

Genetic architecture of individual variation in recombination rate in the X-chromosome in cattle. Zhang J, Kadri NK, Mullaert E, Spelman R, Fritz S, Boichard D, Charlier C, Georges M, Druet THeredity 125: 304-316 (2020).

Theoretical and empirical comparisons of expected and realized relationships for the X chromosome.  Druet T, Legarra A. Genet Sel Evol 52: 50 (2020).

Performances of adaptive MultiBLUP, Bayesian regressions, and weighted-GBLUP approaches for genomics predictions in Belgian Blue beef cattle. Gualdrón Duarte JL, Gori AS, Hubin X, Lourenco D, Charlier C, Misztal I, Druet T. BMC Genomics 21: 545 (2020).

SNP-based quantitatve deconvolution of biological mixtures: application to the detection of cows with subclinical mastitis by whole genome sequencing of tank milk. Coppieters W, Karim L, Georges MGenome Res 30: 1201-1207 (2020).

Genome wide association study of 40 clinical meaurements in eight dog breeds. Momozawa Y, Merveille AC, Battaille G, Wiberg M, Koch J, Willesen JL, Proschowsky HF, Gouni V, Chetboul V, Tiret L, Fredholm M, Seppälä EH, Lohi H, Georges M, Lequarré ASSci Rep 10:6520 (2020).

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases. Klarić L, Tsepilov YA, Stanton CM, Mangino M, Sikka TT, Esko T, Pakhomov E, Salo P, Deelen J, McGurnaghan SJ, Keser T, Vučković F, Ugrina I, Krištić J, Gudelj I, Štambuk J, Plomp R, Pučić-Baković M, Pavić T, Vilaj M, Trbojević-Akmačić I, Drake C, Dobrinić P, Mlinarec J, Jelušić B, Richmond A, Timofeeva M, Grishchenko AK, Dmitrieva J, Bermingham ML, Sharapov SZ, Farrington SM, Theodoratou E, Uh HW, Beekman M, Slagboom EP, Louis E, Georges M, Wuhrer M, Colhoun HM, Dunlop MG, Perola M, Fischer K, Polasek O, Campbell H, Rudan I, Wilson JF, Zoldoš V, Vitart V, Spector T, Aulchenko YS, Lauc G, Hayward C. Sci Adv 6:eaax0301 (2020) .

Genomic footprints of recovery in the European Bison. Druet T, Oleński K, Flori L, Bertrand AR, Olech W, Tokarska M, Kaminski S, Gautier M. J Hered 111:194-203 (2020).

2019  

Defining the genetic control of human blood plasma N-glycome using genome-wide association study. Sharapov SZ, Tsepilov YA, Klaric L, Mangino M, Thareja G, Shadrina AS, Simurina M, Dagostino C, Dmitrieva J, Vilaj M, Vuckovic F, Pavic T, Stambuk J, Trbojevic-Akmacic I, Kristic J, Simunovic J, Momcilovic A, Campbell H, Doherty M, Dunlop MG, Farrington SM, Pucic-Bakovic M, Gieger C, Allegri M, Louis E, Georges M, Suhre K, Spector T, Williams FMK, Lauc G, Aulchenko YS. Hum Mol Genet 28: 2062-2077 (2019).

Essential Role of HTLV-1 orf-I in Lethal Proliferation of CD4+ Cells in Humanized Mice. Galli V, Nixon C, Strbo N, Artesi M, de Castro-Amarante M, McKinnon K, Fujikawa D, Omsland M, Washington Parks R, Romero L, Caruso B, Durkin K, Brown S, Karim B, Vaccari M, Jacobsen S, Zack J, Van den Broeke A, Pise-Masison C, Franchini G.  J Virol 93: e00565-19 (2019).

A random forests framework for modeling haplotypes as mosaics of reference haplotypes. Faux P, Geurts P, Druet T. Front Genet 10:562 (2019).

Harnessing genomic information for livestock improvement. Georges M, Charlier C, Hayes B. Nat Rev Genet 20:135-156 (2019).

2018

Codon-specific translation reprogramming promotes resistance to targeted therapy. Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, De Tullio P, Sin O, Shostak K, Schmitz S, Piepers J, Ghesquière B, Karim L, Charloteaux B, Jamart D,  Florin A,  Lambert C,  Rorive A, Jerusalem G, Leucci E, Dewaele M, Vooijs M, Leidel SA, Georges M, Voz M, Peers B, Buttner R, Marine JC, Chariot A, Close P. Nature 558: 605-6609 (2018)

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N; 23andMe Research Team; AAGC collaborators, Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS, Antó JM, Arnold A, Barreto-Luis A, Baurecht H, van Beijsterveldt CEM, Bleecker ER, Bonàs-Guarch S, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Dmitrieva J, Duijts L, Ege MJ, Gauderman WJ, Georges M, Gieger C, Gilliland F, Granell R, Gui H, Hansen T, Heinrich J, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Jónsdóttir I, Kabesch M, Kaprio J, Kumar A, Lee YA, Levin AM, Li X, Lorenzo-Diaz F, Melén E, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pershagen G, Pino-Yanes M, Probst-Hensch NM, Rüschendorf F, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thiering E, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Bønnelykke K. Nat Genet 50:1072-1080 (2018)

IBD risk loci are enriched in multigenic regulatory modules encompassing causative genes. Momozawa Y, Dmitrieva J, Theatre E, Deffontaine V, Rahmouni S, Charloteaux B, Crins F, Docampo E, Elansary M, Gori A-S, Lecut C, Mariman R, Mni M, Oury C, Altukhov I, Alexeev D, Aulchenko Y, Amininiejad L, Boum G, Hoentjen F, Lowenberg M, Oldenburg B, Pierik MJ, van der Meulen-de Jong AE, van der Woude CJ, Visschedijk MC, The IIBDGC, Lathrop M, Hugot J-P, Weersma RK, De Vos M, Franchimont D, Vermeire S, Kubo M, Louis E, Georges MNat Commun 9:2427 (2018)

Analysis of genes associated with monogenic primary immunodeficiency identifies rare variants in XIAP in patients with Crohn's disease. Amininejad L, Charloteaux B, Theatre E, Liefferinckx C, Dmitrieva J, Hayard P, Muls V, Maisin J-M, Shapira M, Ghislain J-M, Closset P, Talib M, Abramowicz M, Momozawa Y, Deffontaine V, Crins F, Mni M, Karim L, Cambisano N, Ormenese S, Zucchi A, Minsart C, Deviere J, Hugot J-P, De Vos M, Louis E, Vermeire S, Van Gossum A, Coppieters W, Twizere J-C, Georges M, Franchimont D, IIBDGC.  Gastroenterology 154:2165-2177 (2018)

PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1 infected humanized mice. Pérès E, Blin J, Ricci EP, Artesi M, Hahaut V, Van den Broeke A, Corbin A, Gazzalo L, Ratner L, Jalinot P, Duc Dodon M. PLoS Pathog. 14:e1006933 (2018)

2017

Age-based partitioning of individual genomic inbreeding levels in Belgian Blue Cattle. Solé, M, Gori AS, Faux P, Bertrand A, Farnir F, Gautier M, Druet T. Genet Sel Evol 49: 92 (2017)

A model-based approach to characterize individual inbreeding at both global and local genomic scales. Druet T, Gautier M. Mol Ecol 26: 5820-5841 (2017)

Monitoring Molecular Response in Adult T-cell Leukemia/Lymphoma by High-Throughput Sequencing Analysis of HTLV-1 Clonality. Artesi M, Marçais A, Durkin K, Rosewick N, Hahaut V, Suarez P, Trinquand A, Lhermitte L, Avettand Fenoel V, Georges M, Hermine O & Van den Broeke ALeukemia 31: 2532-2535 (2017)

CCDC88B is required for pathogeneisis of inflammatory bowel disease. Fodil N, Moradin N, Yeretssian G, Leung V, Cayrol R, Olivier, J-F, Georges M, Theatre E, Momozawa Y, Gros P. Nat Commun 8: 932 (2017)

Fixed-length haplotypes can improve genomic prediction accuracy in an admixed dairy cattle population. Hess M, Druet T, Hess A, Garrick D. Genet Sel Evol 49: 54 (2017)

A strategy to improve phasing of whole-genome sequenced individuals through integration of familial information from dense genotype panels. Faux P, Druet T. Genet Sel Evol 49: 46 (2017)

A de novo missense mutation of FGFR2 causes facial dysplasia syndrome in Holstein cattle. Agerholm JA,  McEvoy F, Heegaard S, Charlier C, Jagannathan V, Drogemuller C. BMC Genetics 18:74 (2017)

Association mapping of inflammatory bowel disease loci to single variant resolution. Huang H*, Fang M*, Jostins L*, Umicevic Mirkov M, Boucher G, Anderson CA, Andersen V, Cleynen I, Cortes A, Crins F, D'Amato M, Deffontaine V, Dmitrieva J, Docampo E, Elansary M, Kai-How Farh K, Franke A, Gori A-S, Goyette P, Halfvarson, Haritunians T, Knight J, Lawrance IC, Lees CW, Louis E, Mariman R, Meuwissen T, Mni M, Momozawa Y, Parkes M, Spain SL, Theatre E, Trynka G, Satsangi J, van Sommeren S, Vermeire S, Xavier RJ, IIBDGC, Weersma R, Duerr RH, Mathew CG, Rioux JD, McGovern DPB, Cho JH, Georges M#, Daly M#, Barrett JC.# *co-first, #co-senior Nature 547: 173-178 (2017)

HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation. Percher F, Curis C, Peres E, Artesi M,  Rosewick N, Jeannin P, Gessain A, Gout O, Mahieux R, Ceccaldi P-E, Van den Broeke A, Duc Dodon M, PV Afonso. Nat Commun 8: 15890 (2017)

Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis. Rosewick N, Durkin K, Marçais A, Artesi M, Hahaut V, Griebel P, Arsic N, Avettan-Fenoel V, Burny A, Charlier C, Hermine O, Georges M, Van den Broeke ANat Commun 8: 15264 (2017)

Genome-Wide Association Study of Acute Renal Graft Rejection. Ghisdal L, Baron C, Lebranchu Y, Viklický O, Konarikova A, Naesens M, Kuypers D, Dinic M, Alamartine E, Touchard G, Antoine T, Essig M, Rerolle JP, Merville P, Taupin JL, Le Meur Y, Grall-Jezequel A, Glowacki F, Noël C, Legendre C, Anglicheau D, Broeders N, Coppieters W, Docampo E, Georges M, Ajarchouh Z, Massart A, Racapé J, Abramowicz D, Abramowicz M. Am J Transplant: 17:201-209 (2017)

2016

An Intronic MBTPS2 Variant Results in a Splicing Defect in Horses with Brindle Coat Texture. Murgiano L, Waluk DP, Towers R, Wiedemar N, Dietrich J, Jagannathan V, Drögemüller M, Balmer P, Druet T, Galichet A, Penedo MC, Müller EJ, Roosje P, Welle MM, Leeb T. G3 (Bethesda). 2016 Sep 8;6(9):2963-70.

Frequency of mosaicism points towards mutation-prone early cleavage cell divisions. Harland C, Charlier C, Karim L, Cambisano N, Deckers M, Mullaert E, Coppieters W, Georges M. http://biorxiv.org/content/early/2016/10/09/079863

BayesFM: a software program to fine-map multiple causative variants in GWAS identfied risk loci. Fang M, Georges M. http://dx.doi.org/10.1101/067801

NGS-based reverse genetic screen for embryonic lethal mutations compromising fertility in livestock. Charlier C, Li W, Harland C, Littlejohn M, Coppieters W, Creagh F, Druet T, Faux P, Guillaume F, Karim L, Keehan M, Davis S, Kumar-Kadri N, Spelman R, Georges M. Genome Res  26: 1333-1341 (2016)

Coding and non-coding variants in HFM1, MLH3, MSH4, MSH5, RNF212 and RNF21Z2B affect recombination rate in cattle. Kadri NK, Harland C, Faux P, Cambisano N, Karim L, Coppieters W, Fritz S, Mullaart E, Baurain D, Boichard D, Spelman R, Charlier C, Georges M & Druet TGenome Res 26: 1323-1332 (2016)

Expression of Evc2 in craniofacial tissues and craniofacial bone defects in Evc2 knockout mouse. Badri MK, Zhang H, Ohyama Y, Venkitapathi S, Alamoudi A, Kamiya N, Takeda H, Ray M, Scott G, Tsuji T, Kunieda T, Mishina Y, Mochida Y. Arch Oral Biol. 68:142-152 (2016). 

Ellis van Creveld2 is required for postnatal craniofacial bone development. Badri MK, Zhang H, Ohyama Y, Venkitapathi S, Kamiya N, Takeda H, Ray M, Scott G, Tsuji T, Kunieda T, Mishina Y, Mochida Y. Anat Rec 299 (2016).

Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease. Cleynen I, Konings P, Robberecht C, Laukens D, Amininejad L, Théâtre E, Machiels K, Arijs I, Rutgeerts P, Louis E, Franchimont D, De Vos M, Van Steen K, Georges M, Moreau Y, Vermeesch J, Vermeire S. Inflamm Bowel Dis. 22:505-515 (2016)

Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts by deep sequencing reveals their constitutive expression in tumors and transcriptional interaction with viral microRNAs. Durkin K, Rosewcik N, Artesi M, Hahaut V, Griebel P, Arsic N, Burny A, Georges M, Van den Broeke ARetrovirology 13:33 (2016)

Reverse genetic screen for loss-of-function mutations uncovers a frameshifting deletion in the melanophilin gene accountable for a distinctive coat color in Belgian Blue Cattle. Li W, Sartelet A, Tamma N, Coppieters W, Georges M, Charlier C. Animal Genetics 47:110-113 (2016)

2015

Generation of Evc2/Limbin global and conditional KO mice and its role during mineralized tissue formation. Zhang H, Takeda H, Tsuji T, Kamiya N, Rajderkar S, Louie K, Collier C, Scott G, Ray M, Mochida Y, Kaartinen V, Kunieda T, Mishina Y. Genesis,  Jul 28. doi: 10.1002/dvg.22879. [Epub ahead of print] (2015) 

Ectopic expression of Retroposon-Derived PEG11/RTL1 contributes to the callipyge muscular hypertrophy. Xu X, Davis E, Ectors F, Farnir F, Cockett N, Charlier C, Georges M, Takeda H. PLoS One 10: e140594 (2015)

A stop-gain in the laminin alpha 3 gene causes recessive junctional epidermolysis bullosa in Belgian Blue Cattle. Sartelet A, Harland C, Tamma N, Karim L, Bayrou C, Li W, Ahariz N, Coppieters W, Georges M, Charlier C. Animal Genetics 46: 566-570 (2015)

On the use of the transmission disequilibrium test to detect pseudoautosomal variants affecting traits with sex-limited expression. Elansary M, Stinckens A, Ahariz N, Cambisano N, Coppieters W, Grindflek E, Buys N, Georges M. Animal Genetics 46: 395-402 (2015)

High density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflamatory bowels diseases and heterozygous advantage in ulcerative colitis. Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva E, Annese V, Hauser S.L, Oksenberg J.R, Thomsen I, Leslie S, Théâtre E, Georges M, Louis E, Daly M, Van Steen K, Duerr R. H, Barrett J.C, McGovern D.p, Schumm L;P, Traherne J.A, Carrington M.N, Kosmoliaptis V, Karlsen T.H, Franke A, Rioux J.D Nat Genetics 47: 172-9 (2015)

Genome Wide Copy number variation scan identifies complement component C4 as novel suceptibility gene for Crohn's disease. Cleynen I, Konings P, Robberecht C, Laukens D, Amininejad L, Théâtre E, Machiels K, Arijs I, Rutgeerts P, Louis E, Franchimont D, De Vos M, Van Steen K, Georges M, Moreau Y, Vermeesch J, Vermeire S. Inflammatory bowel diseases 22:505-515 (2015)

Genome-wide next generation DNA and RNA sequencing reveals a mutation that perturbs splicing of the phosphatidylinositol glycan anchor biosynthesis class H gene (PIGH) and causes arthrogryposis in belgian Blue Cattle. Sartelet A, Li W, Pailhoux E, Richard C, Tamma N, Karim L, Fasquelle C, Druet T, Coppieters W, Georges M, Charlier C. BMC Genomics 16: 316 (2015)

LINKPHASE3: an improved pedigree-based phasing algorithm robust to genotyping and map errors. Druet T, Georges M Bioinformatics 31: 1677-1679 (2015)

2014 

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra Mde L, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA. N Engl J Med 371:2363-2374 (2014)

Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle. Littlejohn MD, Henty KM, Tiplady K, Johnson T, Harland C, Lopdell T, Sherlock RG, Li W, Lukefahr SD, Shanks BC, Garrick DJ, Snell RG, Spelman RJ, Davis SR. Nat Commun 5: 5861 (2014)

Experimental evaluation of the effect of microRNAs from the callipyge domain on DLK1 expression. Cheng H, Xu X, Hadfield T, Cockett N, Charlier C, Georges M, Takeda H. BMC Genomics 15:944 (2014)

Selection in action: dissecting the molecular underpinnings of the increasing muscle mass of Belgian Blue Cattle. Druet T, Ahariz, N, Cambisano N, Tamma N, Michaux C, Coppieters W, Charlier C, Georges M. BMC Genomics 15:796 (2014)

Towards sequenced-based genomic selection of cattle. Georges M. Nature Genetics 46:807-808 (2014)

Efficiency of haplotype-based methods to fine-map QTLs and embryonic lethal variants affecting fertility: Illustration with a deletion segregating in Nordic Red cattle. Kadri NK, Sahana G, Guldbrandtsen B, Lund MS, Druet T. Livestock Science 166:167–175 (2014)

A 660-Kb deletion with antagonistic effects on fertility and milk production segregates at high frequency in Nordic Red cattle: additional evidence for the common occurrence of balancing selection in livestock. Kumar Kadri N, Sahana G, Charlier C, Iso-Touru T, Guldbrandten B, Karim L, Nielsen US, Panitz F, Aamand GP, Schulman N, Georges M, Vilkki J, Lund MS, Druet T. PloS Genetics 10:E1004049 (2014)

A missense mutation accelerating the gating of the lysosomal Cl-/H+ exchanger ClC-7/Ostm1 causes osteopetrosis with gingival hamartomas in cattle. Sartelet A, Stauber T, Coppieters W, Ludwig C, Fasquelle C, Druet T, Zhang Z, Ahariz N, Cambisano N, Jentsch TJJ, Charlier C. Dis Model Mech 7: 119-128 (2014)

Error rate for imputation from the Illumina BovineSNP50 chip to the Illumina BovineHD chip. Schrooten C, Dassonneville R, Ducrocq V, Brøndum RF, Lund MS, Chen J, Liu Z, González-Recio O, Pena J, Druet T. Genetics Selection Evolution, 46(1), 10 (2014)

Towards genomic prediction from whole genome sequence data: impact of sequencing design on genotype imputation and accuracy of prediction. Druet T, Macleod IM, Hayes BJ. Heredity 112:39-47 (2014)

2013

Use of ancestral haplotypes in genome-wide association studies. Druet T, Farnir F. Methods Mol Biol. 2013;1019:347-80.

A genome scan conducted in a multigenerational pedigree with convergent strabismus supports a complex genetic determinism. Georges A, Cambisano N, Ahariz N, Karim L, Georges M. PLoS One 8(12): e83574 (2013).

Cis- and trans-effects underlying polar overdominance at the callipyge locus. Georges M, Takeda H, Cheng H, Xu X, Hadfield T, Cockett N, Charlier C. Epigenetics and Complex Traits. Editors:Naoumova AK & Greenwood CMT. Springer, New York.

Identification of large selective sweeps associated with major genes in cattle. Druet T, Perez-Pardal L, Charlier C, Gautier M. Animal Genetics 44: 758-762 (2013)

A triad of highly divergent polymeric immunoglobulin receptor (PIGR) haplotypes with major effect on IgA concentration in cow's milk. Berry S, Coppieters W, Davis S, Palmzer D, Kelly V, Burrett A, Ward H, Smith A, Thomas N, Spelman R, Sanders K, Georges M, Lehnert K, Snell R. PLoS One 8(3):e57219 (2013).

Deep sequencing reveals abundant class of retroviral microRNAs in BLV-induced leukemia. Rosewick N, Durkin K, Momont M, Takeda H, Caiment F, Cleuter Y, Vernin C, Mortreux F, Wattel E, Burny A, Georges M, Van den Broeke A. Proc Natl Acad Sci USA 110:2306-2311 (2013).

 

2012 

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Büning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H; International IBD Genetics Consortium (IIBDGC), Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC, Cho JH.
Nature 491:119-124 (2012)

 

LDSO: a program to simulate pedigrees and molecular information under various evolutionary forces.

Ytournel F, Teyssèdre S, Roldan D, Erbe M, Simianer H, Boichard D, Gilbert H, Druet T, Legarra A.
J Anim Breed Genet. 129:417-421 (2012)

 

A deletion in the bovine FANCI gene compromises fertility by causing fetal death and brachyspina.

Charlier C, Agerholm JS, Coppieters W, Karlskov-Mortensen P, de Jong G, Li W, Fasquelle C, Karim L, Cambisano N, Ahariz N, Mullaart E, Georges M, Fredholm M.

PLoS One 7:e43085 (2012)

 

Ancestral haplotype-based association mapping with generalized linear mixed models accounting for stratification.

Zhang Z, Sartelet A, Charlier C, Georges M, Farnir F, Druet T
Bioinformatics 28:2467-2473 (2012)

 

Genetic variants in REC8, RNF212 and PRDM9 influence male recombination in cattle.

Sandor C, Li W, Coppieters W, Druet T, Charlier C, Georges M
PLoS Genetics 8:e1002854 (2012)

 
Identifying cows with subclinical mastitis by bulk SNP genotyping of tank milk.

Blard G, Zhang Z, Coppieters W, Georges M
J Dairy Sc 95:4109-4113 (2012).

 
Fast homozygosity mapping and identification of a zebrafish ENU-induced mutation by high-throughput sequencing.

Voz ML, Coppieters W, Manfroid I, Baudhuin A, Von berg V, Charlier C, Meyer D, Driever W, Martial JA, Peers B
PLoS One 7:e34671 (2012).


Detection of Copy Number Variants in the horse genome and examination of their association with Recurrent Laryngeal Neuropathy

Dupuis M-C, Zhang Z, Durkin K, Charlier C, Lekeux P, Georges M
Animal Genet 44:206-208.

 

A splice site variant in the bovine RNF11 gene compromises grwoth and regulation of the inflammatory response.

Sartelet A, Druet A, Michaux C, Fasquelle C, Géron S, Tamma N, Zhang Z,Coppieters W, Georges M, Charlier C
PLoS Genetics 8:e1002581 (2012).

 

Impact of high-throughput genotyping and sequencing on the identification of genes and variants underlying phenotypic variation in domestic cattle.

Georges M
in "Bovine Genomics", Editor: James Womack. Wiley Blackwell.

 

Imputation of genotypes with low-density chips and its effect on reliability of direct genomic values in Dutch Holstein cattle.

Mulder HA, Calus MP, Druet T, Schrooten C.
J Dairy Sci. 95:876-889 (2012)

 

Serial translocation via circular intermediates underlies color-sidedness in cattle.

Durkin K, Coppieters W, Drögemüller C, Ahariz N, Cambisano N, Fasquelle C, Haile A, Horin P, Huang L. Karim L, Moser S, Oldenbroek K, Rieder S, Sartelet A, Solkner J, Stalhammer H, Leeb T, Georges M, Charlier C.

Nature 482:81 - 84 (2012)

 

Genetic variation in PLAG1 associates with early life body weight and peripubertal weight and growth in Bos taurus.

Littlejohn M, Grala T, Sanders K, Walker C, Waghorn G, Macdonald K, Coppieters W, Georges M, Spelman R, Hillerton E, Davis S, Snell R.
Anim Genet 43:591-594 (2012).

 

Allelic heterogeneity of Crooked Tail Syndrome fits the balancing selection hypothesis.

Sartelet A, Klingbeil P, Franklin C, Fasquelle C, Geron S, Isacke C, Georges M, Charlier C
Animal Genetics 43:604-607 (2012).

 

2011 -BACK

 

 

 

A common reference population from four European Holstein populations increases reliability of genomic predictions.

Lund MS, Roos AP, Vries AG, Druet T, Ducrocq V, Fritz S, Guillaume F, Guldbrandtsen B, Liu Z, Reents R, Schrooten C, Seefried F, Su G.
Genet Sel Evol. Dec 12:43:43 (2011)

 

LUPA: A European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs.

Lequarré AS, Andersson L, André C, Fredholm M, Hitte C, Leeb T, Lohi H, Lindblad-Toh K, Georges M.

Vet J. 189: 155-159 (2011)

 

Results of a haplotype-based GWAS for Recurrent Laryngeal Neuropathy in the horse.

Dupuis M-C, Zhang Z, Druet T, Denoix J-M, Charlier C, Lekeux P, Georges M.
Mammalian Genome 22:613-620 (2011)

 

Genomic breeding value estimation using genetic markers, inferred ancestral haplotypes, and the genomic relationship matrix.

de Roos AP, Schrooten C, Druet T.
J Dairy Sci. 94:4708-4714 (2011)

 

Effect of imputing markers from a low-density chip on the reliability of genomic breeding values in Holstein populations.

Dassonneville R, Brøndum RF, Druet T, Fritz S, Guillaume F, Guldbrandtsen B, Lund MS, Ducrocq V, Su G.
J Dairy Sci. 94:3679-3686 (2011)

 

Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature.

Karim L, Takeda H, Lin L, Druet T, Arias JAC, Baurain D, Cambisano N, Davis SR, Farnir F, Grisart B, Harris BL, Keehan MD, Littlejohn MD, Spelman RJ, Georges M, Coppieters W. 
Nature Genetics 43: 405-413 (2011)

 

Resolving difficult phylogenetic questions: why more sequences are not enough.

Philippe H, Brinkmann H, Lavrov DV, Littlewood DT, Manuel M, Wörheide G, Baurain D.
PLoS Biol 9:e1000602 (2011).

 

Modeling of identity-by-descent processes along a chromosome between haplotypes and their genotyped ancestors.

Druet T, Farnir F
Genetics  188:409-419  (2011)

 

The long and winding road from correlation to causation. 

Georges M. 
Nature Genetics 43:180-181 (2011)

 

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. 

Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD. 
Nature Genetics 43: 246-252 (2011)

 

Characterization of bacteria in biopsies of colon and stools by high-throughput sequencing of the V2 region of bacterial 16 rRNA gene in human.

Momozawa Y, Deffontaine V, Louis E, Medrano J
Plos One 6:e16952 (2011)

 

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease.

Momozawa Y, Mni M, Nakamura K, Coppieters W, Almer S, Amininejad L, Dewit O, Finkel Y,Gassuli MA, Goossens D, Laukens D, Lémann M, Libioulle C, O'Morain C, Reenaers C, Rutgeerts P, Tysk C, Zelenika D, Lathrop M, Del-Favero J, Hugot JP, de Vos M, Franchimont D, Vermeire S, Louis E, Georges M. 
Nature Genetics 43:43-47 (2011) Supplementary information

 

CDC39 is required for assembly of inner dynein arms and the dynein regulatory complex as well as normal ciliary motility in human and dogs. 

Merveille AC, Davis E, Becker-Heck A, Legendre M, Amirav I, Bataille G, Belmont J, Beydon N, Billen F, Clément A, Clercx C, Coste A, Crosbie R, de Blic J, Deleuze S, Duquesnoy P, Escalier D, Escudier E, Fliegauf M,  Horvath J, Hill K,Jorissen M, Just J, Kispert A, Lathrop M, Tomas Loges N, Marthin JK,  Momozawa Y, Montantin G, Nielsen KG, Olbrich H, Papon JF, Rayet I, Roger G, Schmidts M, Tenreiro H, Towbin JA, Zelenika D, Zentgraf H, Georges M, Lequarré AS, Katsanis N, Omran H, Amselem S. 
Nature Genetics 43:72-78 (2011) Supplementary information

 

 

2010 - BACK

 

 

 

 

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M.
Nature Genetics 42:1118-1125 (2010)


When less means more: impact of the discovery of myostatin in animal breeding.

Georges M.
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 10:240-248 (2011)

 

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.

Laukens D, Georges M, Libioulle C, Sandor C, Mni M, Vaner Cruyssen B, Peeters H, Elewaut D, De Vos M.
Plos One 5:e13795 (2010)

 

Assessing the effect of the CLPG mutation on the microRNA catalogue of skeletal muscle using high throughput sequencing.

Caiment F, Charlier C, Hadfield T, Cockett N, Georges M, Baurain D.
Genome Research 20:1651-1662 (2010). Supplemental material.

 

Does probabilistic modelling of linkage disequilibrium evolution improve the accuracy of QTL location in animal pedigree?

Cierco-Ayrolles C, Dejean S, Legarra A, Gilbert H, Druet T, Ytournel F, Estivals D, Oumouhou N, Mangin B.
Genet Sel Evol. 42:38 (2010)

 

Marker imputation with low-density marker panels in Dutch Holstein cattle.

Zhang Z, Druet T
J Dairy Sci. 93:5487-5494 (2010)


Imputation of genotypes from different single nucleotide polymorphism panels in dairy cattle. 

Druet T, Schrooten C, de Roos AP.
J Dairy Sci. 93:5443-5454 (2010)


Demonstrating polymorphic miRNA-mediated gene regulation in vivo: application to the g+6223G->A mutation of Texel sheep.

Takeda H, Charlier C, Farnir F, Georges M.
RNA 16:1854-1863 (2010)


Dissection moléculaire de la prédisposition innée aux maladies inflammatoires chroniques de l’intestin : liaison génétique, gènes candidats, et études d’association génome entier. 

Georges M, Libioulle C, Louis E.
In Maladies inflammatoires chroniques de l’intestin. Progrès en Hépato-Gastroentérologie 11 (2010). 

 

Phylogenomic evidence for separate acquisition of plastids in cryptophytes, haptophytes, and stramenopiles.

Baurain D, Brinkmann H, Petersen J, Rodríguez-Ezpeleta N, Stechmann A, Demoulin V, Roger AJ, Burger G, Lang BF, Philippe H.
Mol Biol Evol 27:1698-1709 (2010).

 

Atypical subunit composition of the chlorophycean mitochondrial F1FO-ATP synthase and role of Asa7 protein in stability and oligomycin resistance of the enzyme.

Lapaille M, Escobar-Ramírez A, Degand H, Baurain D, Rodríguez-Salinas E, Coosemans N, Boutry M, Gonzalez-Halphen D, Remacle C, Cardol P.
Mol Biol Evol 27:1630-1644 (2010).

 

Indirect effect of IGF2 intron3g.3072G>A mutation on prolificacy in sows.

Stinckens A, Mathur P, Janssens S, Bruggeman V, Onagbesan OM, Schroyen M, Spincemaille G, Decuypere E, Georges M, Buys N.
Animal Genetics April 14th (2010)


A hidden markov model combining linkage and linkage disequilibrium information for haplotype reconstruction and quantitative trait locus fine mapping.
Druet T, Georges M

Genetics 184:789-798 (2010)


Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates.

Hiard S, Charlier C, Coppieters W, Georges M, Baurain D.
Nucleic Acids Res. 38(Database issue):D640-51 (2010)

 

Correlative responses for carcass and meat quality traits to selection for ovulation rate or prenatal survival in French Large White pigs.

Rosendo A, Druet T, Péry C, Bidanel JP.
J Anim Sci. 88:903-911 (2010)

 

 

2009 - BACK

 

 


Common variants at five new loci associated with early-onset inflammatory bowel disease.
Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D; Western Regional Alliance for Pediatric IBD, Silber G, Wrobel I, Quiros A; International IBD Genetics Consortium, Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmuda MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ; NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwillam R, Tremelling M, Delukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Silverberg MS, Satsangi J, Hakonarson H.
Nature Genetics 41:1335-1340 (2009)

 

A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle.

Koltes JE, Mishra BP, Kumar D, Kataria RS, Totir LR, Fernando RL, Cobbold R, Steffen D, Coppieters W, Georges M, Reecy JM.
Proc Natl Acad Sci U S A. 106:19250-19255 (2009)

 

Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies.

Katrincsakova B, Takeda H, Urbankova H, Michaux L, Jarosova M, Vandenberghe P, Georges M, Charlier C, Wlodarska I.
Epigenetics 4:469-475 (2009)


Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle.

Fasquelle C, Sartelet A, Li W, Dive M, Tamma N, Michaux C, Druet T, Huijbers IJ, Isacke CM, Coppieters W, Georges M, Charlier C.
PLoS Genetics 5:e1000666 (2009)


Interactions between genes involved in growth and muscularity in pigs: IGF-2, myostatin, ryanodine receptor 1, and melanocortin-4 receptor.

Stinckens A, Luyten T, Van den Maagdenberg K, Janssens S, De Smet S, Georges M, Buys N.
Domest Anim Endocrinol. 37:227-235 (2009)


Genetics of ulcerative colitis: the come-back of interleukin 10.

Louis E, Libioulle C, Reenaers C, Belaiche J, Georges M.
Gut 58:1173-1176 (2009)


Mapping QTL influencing gastrointestinal nematode burden in Dutch Holstein-Friesian dairy cattle.

Coppieters W, Mes TH, Druet T, Farnir F, Tamma N, Schrooten C, Cornelissen AW, Georges M, Ploeger HW.
BMC Genomics 10:96 (2009)

 

A high density linkage map of the bovine genome.

Arias JA, Keehan M, Fisher P, Coppieters W, Spelman R.
BMC Genetics 10:18 (2009)  

 

 

 2008 - BACK

 

 


Investigation of the fine structure of European populations with applications to disease association studies.
Heath SC, Gut IG, Brennan P, McKay JD, Bencko V, Fabianova E, Foretova L, Georges M, Janout V, Kabesch M, Krokan HE, Elvestad MB, Lissowska J, Mates D, Rudnai P, Skorpen F, Schreiber S, Soria JM, Syvänen AC, Meneton P, Herçberg S, Galan P, Szeszenia-Dabrowska N, Zaridze D, Génin E, Cardon LR, Lathrop M.
Eur J Hum Genet. 16:1413-1429 (2008)

 

Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomes.
Van Laere AS, Coppieters W, Georges M.
Genome Research 18:1884-1895 (2008)

 

Characterization of the complete porcine MSTN gene and expression levels in pig breeds differing in muscularity.
Stinckens A, Luyten T, Bijttebier J, Van den Maagdenberg K, Dieltiens D, Janssens S, De Smet S, Georges M, Buys N
Animal Genetics 39:586-596 (2008)

 

On the detection of imprinted quantitative trait loci in line crosses: effect of linkage disequilibrium.
Sandor C, Georges M.
Genetics 180:1167-1175 (2008)

 

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ; NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ.
Nature Genetics 40:955-962 (2008) (Suppl. Mat.)

 

Highly effective SNP-based association mapping and management of recessive defects in livestock.
Charlier C, Coppieters W, Rollin F, Desmecht D, Agerholm JS, Cambisano N, Carta E, Dardano S, Dive M, Fasquelle C, Frennet JC, Hanset R, Hubin X, Jorgensen C, Karim L, Kent M, Harvey K, Pearce BR, Simon P, Tama N, Nie H, Vandeputte S, Lien S, Longeri M, Fredholm M, Harvey RJ, Georges M.
Nature Genetics 40:449-454 (2008) (Suppl. Mat.)

 

 

2007 - BACK

 

Mapping, fine mapping, and molecular dissection of quantitative trait Loci in domestic animals.

Georges M.
Annu Rev Genomics Hum Genet. 8:131-162 (2007)

 

Polymorphic miRNA-mediated gene regulation: contribution to phenotypic variation and disease.

Georges M, Coppieters W, Charlier C.
Curr Opin Genet Dev. 17:166-176 (2007)

 

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.

Libioulle C, Louis E, Hansoul S, Sandor C, Farnir F, Franchimont D, Vermeire S, Dewit O, de Vos M, Dixon A, Demarche B, Gut I, Heath S, Foglio M, Liang L, Laukens D, Mni M, Zelenika D, Van Gossum A, Rutgeerts P, Belaiche J, Lathrop M, Georges M.
PLoS Genetics 3:e58 (2007)

 

The RYR1 g.1843C>T mutation is associated with the effect of the IGF2 intron3-g.3072G>A mutation on muscle hypertrophy.

Stinckens A, Van den Maagdenberg K, Luyten T, Georges M, De Smet S, Buys N.
Animal Genetics 38:67-71 (2007) 

 

Differential expression of sarcoplasmic proteins in four heterogeneous ovine skeletal muscles.

Hamelin M, Sayd T, Chambon C, Bouix J, Bibé B, Milenkovic D, Leveziel H, Georges M, Clop A, Marinova P, Laville E.
Proteomics 7:271-280 (2007) 

 

 

2006 - BACK

 

Polymorphic microRNA-target interactions: a novel source of phenotypic variation.

Georges M, Clop A, Marcq F, Takeda H, Pirottin D, Hiard S, Tordoir X, Caiment F, Meish F, Bibé B, Bouix J, Elsen JM, Eychenne F, Laville E, Larzul C, Milenkovic D, Tobin J, Charlier AC.
Cold Spring Harb Symp Quant Biol. 71:343-50 (2006)

 

A 2.5-Mb contig constructed from Angus, Longhorn and horned Hereford DNA spanning the polled interval on bovine chromosome 1. 

Wunderlich KR, Abbey CA, Clayton DR, Song Y, Schein JE, Georges M, Coppieters W, Adelson DL, Taylor JF, Davis SL, Gill CA.
Anim Genet. 37:592-594 (2006)

 

Results of a whole-genome quantitative trait locus scan for growth, carcass composition and meat quality in a porcine four-way cross.

Harmegnies N, Davin F, De Smet S, Buys N, Georges M, Coppieters W.
Anim Genet. 37:543-553 (2006)

 

Proteomic analysis of ovine muscle hypertrophy. 

Hamelin M, Sayd T, Chambon C, Bouix J, Bibé B, Milenkovic D, Leveziel H, Georges M, Clop A, Marinova P, Laville E.
J Anim Sci. 84:3266-3276 (2006)

 

Genetical metabolomics of flavonoid biosynthesis in Populus: a case study.

Morreel K, Goeminne G, Storme V, Sterck L, Ralph J, Coppieters W, Breyne P, Steenackers M, Georges M, Messens E, Boerjan W.
Plant J. 47:224-237 (2006)

 

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep.

Clop A, Marcq F, Takeda H, Pirottin D, Tordoir X, Bibé B, Bouix J, Caiment F, Elsen JM, Eychenne F, Larzul C, Laville E, Meish F, Milenkovic D, Tobin J, Charlier C, Georges M.
Nature Genetics 38:813-818 (2006)(Suppl. Mat.)(N&V)

 

The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein production in Finnish Ayrshire dairy cattle.

Viitala S, Szyda J, Blott S, Schulman N, Lidauer M, Mäki-Tanila A, Georges M, Vilkki J.
Genetics 173:2151-2164 (2006)

 

Measuring the extent of linkage disequilibrium in commercial pig populations.

Harmegnies N, Farnir F, Davin F, Buys N, Georges M, Coppieters W.
Anim Genet. 37:225-231 (2006)

 

The callipyge mutation enhances bidirectional long-range DLK1-GTL2 intergenic transcription in cis.

Takeda H, Caiment F, Smit M, Hiard S, Tordoir X, Cockett N, Georges M, Charlier C.
Proc Natl Acad Sci USA 103:8119-8124 (2006)

 

Linkage disequilibrium on the bovine X chromosome: characterization and use in quantitative trait locus mapping.

Sandor C, Farnir F, Hansoul S, Coppieters W, Meuwissen T, Georges M.
Genetics 173:1777-1786 (2006)

 

Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat.

Quan X, Laes JF, Stieber D, Rivière M, Russo J, Wedekind D, Coppieters W, Farnir F, Georges M, Szpirer J, Szpirer C.
Mamm Genome 17:310-321 (2006)

 

 

2005 - BACK

 

RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus.

Davis E, Caiment F, Tordoir X, Cavaillé J, Ferguson-Smith A, Cockett N, Georges M, Charlier C.
Curr Biol 15:743-749 (2005).Supplementary information.

 

Transgenic engineering of male-specific muscular hypertrophy.

Pirottin D, Grobet L, Adamantidis A, Farnir F, Herens C, Daa Schrøder H, Georges M.
Proc Natl Acad Sci U S A 102:6413-6418 (2005). 

 

The callipyge mutation and other genes that affect muscle hypertrophy in sheep.

Cockett NE, Smit MA, Bidwell CA, Segers K, Hadfield TL, Snowder GD, Georges M, Charlier C.
Genet Sel Evol 37 Suppl 1:S65-81 (2005)

 

BEGAIN: a novel imprinted gene that generates paternally expressed transcripts in a tissue- and promoter-specific manner in sheep.

Smit MA, Tordoir X, Gyapay G, Cockett NE, Georges M, Charlier C.
Mamm Genome 16:801-814 (2005).

 

 

2004 - BACK

 

 

 

Toward molecular understanding of polar overdominance at the ovine callipyge locus.

Georges M, Charlier C, Smit M, Davis E, Shay T, Tordoir X, Takeda H, Caiment F, Cockett N.
Cold Spring Harb Symp Quant Biol. 69:477-483 (2004).

 

Effects of a quantitative trait locus for muscle hypertrophy from Belgian Texel sheep on carcass conformation and muscularity.

Laville E, Bouix J, Sayd T, Bibé B, Elsen JM, Larzul C, Eychenne F, Marcq F, Georges M.
J Anim Sci. 82:3128-3137 (2004).

 

Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype.

Davis E, Jensen CH, Schroder HD, Farnir F, Shay-Hadfield T, Kliem A, Cockett N, Georges M, Charlier C.
Curr Biol. 14:1858-1862 (2004). Supplementary information.

 

Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition.

Grisart B, Farnir F, Karim L, Cambisano N, Kim JJ, Kvasz A, Mni M, Simon P, Frère JM, Coppieters W, Georges M.
Proc Natl Acad Sci U S A. 101:2398-23403 (2004). Supplementary information 1. Supplementary information 2.

 

Domestic-animal genomics: deciphering the genetics of complex traits.

Andersson L, Georges M.
Nat Rev Genet. 5:202-212 (2004).

 

Detection and characterization of SNPs useful for identity control and parentage testing in major European dairy breeds.

Werner FA, Durstewitz G, Habermann FA, Thaller G, Krämer W, Kollers S, Buitkamp J, Georges M, Brem G, Mosner J, Fries R.
Anim Genet. 35:44-49 (2004).

 

 

2003 - BACK

 

Positional identification of structural and regulatory quantitative trait nucleotides in domestic animal species.

Georges M, Andersson L.
Cold Spring Harb Symp Quant Biol. 68:179-187 (2003).


A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig.

Van Laere AS, Nguyen M, Braunschweig M, Nezer C, Collette C, Moreau L, Archibald AL, Haley CS, Buys N, Tally M, Andersson G, Georges M, Andersson L.
Nature 425:832-836 (2003).


Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene.
Nezer C, Collette C, Moreau L, Brouwers B, Kim JJ, Giuffra E, Buys N, Andersson L, Georges M.
Genetics 165:277-285 (2003).


Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene.
Grobet L, Pirottin D, Farnir F, Poncelet D, Royo LJ, Brouwers B, Christians E, Desmecht D, Coignoul F, Kahn R, Georges M.
Genesis 35:227-238 (2003).


The callipyge locus: evidence for the trans interaction of reciprocally imprinted genes.

Georges M, Charlier C, Cockett N.
Trends Genet 19:248-252 (2003).


Haplotype diversity of the myostatin gene among beef cattle breeds.
Dunner S, Miranda ME, Amigues Y, Cañón J, Georges M, Hanset R, Williams J, Ménissier F.
Genet Sel Evol 35:103-118 (2003).


Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.

Smit M, Segers K, Carrascosa LG, Shay T, Baraldi F, Gyapay G, Snowder G, Georges M, Cockett N, Charlier C.
Genetics 163:453-456 (2003).


Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition.

Blott S, Kim JJ, Moisio S, Schmidt-Küntzel A, Cornet A, Berzi P, Cambisano N, Ford C, Grisart B, Johnson D, Karim L, Simon P, Snell R, Spelman R, Wong J, Vilkki J, Georges M, Farnir F, Coppieters W.
Genetics 163:253-266 (2003). 

 

 

2002 - BACK

 

Amarger V, Nguyen M, Van Laere AS, Braunschweig M, Nezer C, Georges M, Andersson L.
Comparative sequence analysis of the INS-IGF2-H19 gene cluster in pigs.
Mamm Genome 13:388-398 (2002).

 

Nezer C, Moreau L, Wagenaar D, Georges M.
Results of a whole genome scan targeting QTL for growth and carcass traits in a Piétrain x Large White intercross.
Genet Sel Evol 34:371-387 (2002).

 

Farnir F, Grisart B, Coppieters W, Riquet J, Berzi P, Cambisano N, Karim L, Mni M, Moisio S, Simon P, Wagenaar D, Vilkki J, Georges M.
Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14.
Genetics 161:275-287 (2002).

 

Grisart B, Coppieters W, Farnir F, Karim L, Ford C, Berzi P, Cambisano N, Mni M, Reid S, Simon P, Spelman R, Georges M, Snell R.
Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition.
Genome Res 12:222-231 (2002).

 

 

2001 -BACK

 

Paulsen M, Takada S, Youngson NA, Benchaib M, Charlier C, Segers K, Georges M, Ferguson-Smith AC.
Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region.
Genome Res 11:2085-2094 (2001).

 

Bidwell CA, Shay TL, Georges M, Beever JE, Berghmans S, Cockett NE.
Differential expression of the GTL2 gene within the callipyge region of ovine chromosome 18.
Anim Genet 32:248-256 (2001).

 

Charlier C, Segers K, Wagenaar D, Karim L, Berghmans S, Jaillon O, Shay T, Weissenbach J, Cockett N, Gyapay G, Georges M.
Human-ovine comparative sequencing of a 250-kb imprinted domain encompassing the callipyge (clpg) locus and identification of six imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8.
Genome Res 11:850-862 (2001).

 

Charlier C, Segers K, Karim L, Shay T, Gyapay G, Cockett N, Georges M.
The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status.
Nat Genet 27:367-369 (2001).

 

Ikonen T, Bovenhuis H, Ojala M, Ruottinen O, Georges M.
Associations between casein haplotypes and first lactation milk production traits in Finnish Ayrshire cows.
J Dairy Sci 84:507-514 (2001).

 

Berghmans S, Segers K, Shay T, Georges M, Cockett N, Charlier C.
Breakpoint mapping positions the callipyge gene within a 450-kilobase chromosome segment containing the DLK1 and GTL2 genes.
Mamm Genome 12:183-185 (2001).

 

Shay TL, Berghmans S, Segers K, Meyers S, Beever JE, Womack JE, Georges M, Charlier C, Cockett NE.
Fine-mapping and construction of a bovine contig spanning the ovine callipyge locus.
Mamm Genome 12:141-914 (2001).

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